Iron absorption in male C282Y heterozygotes
نویسندگان
چکیده
منابع مشابه
Iron absorption in carriers of the C282Y hemochromatosis mutation.
Hereditary hemochromatosis is a disorder of iron homeostasis in which the body iron content may be greatly increased. Most patients with hereditary hemochromatosis are homozygous for the C282Y mutation of the HFE gene. Because the iron content of the body is regulated by modulation of iron absorption, the increased body iron of those who are homozygous for the C282Y mutation must be due to enha...
متن کاملRedox active plasma iron in C282Y/C282Y hemochromatosis.
Labile plasma iron (LPI) represents the redox active component of non-transferrin-bound iron (NTBI). Its presence in thalassemic patients has been recently reported. The aim of the present study was to quantify LPI in HFE genetic hemochromatosis (GH) and to characterize the mechanisms accounting for its appearance. We studied 159 subjects subdivided into the following groups: (1) 23 with iron o...
متن کاملIron overload in HFE C282Y heterozygotes at first genetic testing: a strategy for identifying rare HFE variants.
BACKGROUND Heterozygotes for the p.Cys282Tyr (C282Y) mutation of the HFE gene do not usually express a hemochromatosis phenotype. Apart from the compound heterozygous state for C282Y and the widespread p.His63Asp (H63D) variant allele, other rare HFE mutations can be found in trans on chromosome 6. DESIGN AND METHODS We performed molecular investigation of the genes implicated in hereditary h...
متن کاملIron absorption by heterozygous carriers of the HFE C282Y mutation associated with hemochromatosis.
BACKGROUND Research conducted before genotyping was possible suggested that subjects heterozygous for the genetic mutation associated with hemochromatosis absorbed nonheme iron more efficiently than did control subjects when tested with a fortified meal. Heme-iron absorption in these subjects has not been reported. OBJECTIVE We compared the absorption of heme and nonheme iron from minimally o...
متن کاملEffect of hemochromatosis genotype and lifestyle factors on iron and red cell indices in a community population.
BACKGROUND Heterozygotes for the C282Y mutation of the HFE gene may have altered hematology indices and higher iron stores than wild-type subjects. METHODS We performed a cross-sectional analysis of 1488 females and 1522 males 20-79 years of age drawn from the Busselton (Australia) population study to assess the effects of HFE genotype, age, gender, and lifestyle on serum iron and hematology ...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2005
ISSN: 0002-9165,1938-3207
DOI: 10.1093/ajcn/81.4.814